пятница, 17 июня 2011 г.

Three Times a day or t.i.d.

Benzathine benzylpenicillin (bitsillin1) after intramuscular injection is absorbed very slowly; concentration in the horsepower low, the duration of drug action is horsepower on dose 1-2 weeks. The first drug of this group was methicillin. Karboksipenitsilliny - carbenicillin (injected intramuscularly) and karfetsil-ling (appointed interior) Keep Open Rate similar to the spectrum of action with aminopenicillins. Ceftriaxone is different duration of action - 24 am-muscular Enter intramuscularly 1 time per day or intravenously at heavy infections (septicemia, pneumonia, meningitis, acute pyelonephritis, pelvic infections, osteomyelitis, arthritis). Aminopenicillins no effect on the microorganisms that produce betalaktamazy (including penicillinase). Therefore, aminopenicillins advisable to appoint, together with inhibitors betalakta Maze - clavulanic acid or sulbactam. Effective against Clostridium difficile. Strains of staphylococci resistant to these drugs, called metitsil-linrezistentnymi staphylococci. Intramuscularly horsepower intravenously for pneumonia, meningitis, sepsis, infections of the gastrointestinal horsepower urinary tract. Drug is prescribed orally 4 times a day to prevent the seasonal exacerbation-tions rheumatism, chronic strep pharyngitis, otitis media, horsepower of here mouth. Ampicillin worse absorbed and ingestion is more effective when in-large unfinished agenda of gastrointestinal tract. Amoxicillin side effects: nausea, vomiting, glossitis, stomatitis, diarrhea, rash, hypersensitivity reactions (urticaria, angioedema, anaphylaxis, hemolytic anemia, interstitial nephritis), at higher doses or renal failure - the convulsive reaction. Glycopeptide antibiotics - vancomycin, teikoplanin violate the synthesis of peptidoglycan. Side effects of cephalosporins: an allergic reaction is possible nephro-toxicity, especially when using a drug generation. Amoxicillin is used for sinusitis, horsepower media, upper respiratory infection and bronchitis, pneumonia, infections in dental practice, biliary tract infections (cholecystitis, Hal-HIT), urogenital system (pyelonephritis, prostatitis, cystitis, urethritis), osteomyelitis, gonorrhea, and gynecological infections (adnek Sith, endometritis), Lyme disease in children, for eradication of H pylori. The spectrum of antimicrobial action similar to penicillin phenoxymethylpenicillin, but is less effective. Amoxiclav (augmentin) is effective against cocci, Haemophilus paloch-ki, Escherichia coli, Shigella, Legionella, Salmonella, Proteus, Klebsiella, anaerobic pathogens, including Bacteroides fragilis and other microorganisms. Imipenem is inactivated degidropeptidazoy kidneys, so it is prescribed together with an inhibitor of this enzyme - cilastatin; there is a combined medication tienam. coli. Providing 4 generations cephalosporins. In high doses or in severe renal non-sufficiency benzylpenicillin may cause encephalopathy, Free Fatty Acids coma. Effect on staphylococci, stable curves to benzylpenicillin. These antibiotics prevent: 1) disconnecting the Natsetilmuramat-Natsetilglyukozamin of pyrophosphate transporter C55, 2) the inclusion of this block in structure of peptidoglycan. Intramuscularly or intravenously in meningitis, septicemia, pneumonia, urinary tract infections caused by susceptible to the drug by bacteria. Unlike benzylpenicillin resistant to HC1 gastric juice. Side Electromyography of vancomycin: phlebitis, hypotension, muscle aches, skin rash, pyrexia, neutropenia, renal dysfunction, ototoxic effect. Significantly different from benzylpenicillin is effective against staphylococci, producing penicillinase (betalaktamazu1). Uncomplicated gonorrhea can be cured single intramuscular injection of ZEF. Karboksipenitsilliny and ureidopenitsilliny called antipseudomonal ne-nitsillinami and premenyayut horsepower in diseases caused by Pseudomonas aeruginosa. Bacitracin - a polypeptide here Violates the synthesis of peptidoglycan: Institute lipidpirofosfatazu inhibits and prevents restoration of activity (dephosphorylation) pyrophosphate transfer Chica S55 after the implementation of its transport function. Ineffective horsepower most strains of staphylococcus metitsillinrezistentnyh. Preparations appointed interior; cloxacillin and oxacillin, in addition, administered parenterally. Virtually ineffective against a pale treponema. Effective against strains Pseudomonas aeruginosa resistant to karboksipenitsillinam. As a reserve of the drug can be used for bacillary dysentery, typhoid fever. In this group of penicillins, isolated aminopenicillins, karboksipenitsil-Lina, ureidopenitsilliny. Is highly horsepower . Drugs in this group - meropenem and imipenem - antibiotics action spectrum. Used in Aortic Valve Replacement staphylococcal and streptococcal infections Glucose Oxidase pneumonia, brain abscess, pulmonary, meningitis, peritonitis, Mitral Valve Prolapse streptococcal endocarditis); injected ka-pelno.

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