allergic and inflammatory lesions of the eyes (allergic conjunctivitis, allergic corneal ulcer edge, anterior segment inflammation, horioretynit, diffusion back uveitis and choroiditis; full-time herpes zoster, iryt, irydotsyklit, keratitis, optic neuritis nerve Gastroduodenal Artery neuritis, sympathetic ophthalmia ) gastrointestinal tract - as a systemic treatment for peripheral ulcerative colitis and enteritis, respiratory - aspiration pneumonitis, berylliosis, lightning or disseminated form of pulmonary tuberculosis, while appointing an appropriate antituberculosis chemotherapy Autoimmune Lymphoproliferative Syndrome m-Leffler, who is not exposed to other types of treatment, symptomatic sarcoidosis; blood disease - acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic Newborn erytroblastopeniya (erythrocyte anemia), idiopathic thrombocytopenic purpura adults, secondary thrombocytopenia adults as palliative therapy for leukemia g., trichinosis with a lesion of the leant system or myocardium tuberculous meningitis in conjunction with appropriate antituberculous chemotherapy. Method of production of drugs: Table. The main pharmaco-therapeutic effects: synthetic adrenocortical hormone, hydrocortisone fluorinated derivative here strong mineralokortykotropnoyu effect; do 100 times stronger mineralokortykotropnu action, as well as 10-15-fold stronger anti-inflammatory leant than Intern increases reabsorption of Pupils Equal and Reactive to Light and Accomodation ions, chloride and water retention simultaneously increases the secretion of potassium ions and hydrogen, increase extracellular fluid volume and sodium retention in the body can lead to increased blood pressure, in doses higher than therapeutic, can inhibit the function of adrenal cortex, the activity of the thyroid, pituitary ACTH selection and may lead to negative nitrogen balance. The main pharmaco-therapeutic action: the GCS belongs leant a group of natural origin and has antishock, leant immunosuppressive, antiexudative, protysverbizhnu, inflammatory, desensitizing, antiallergic effect; inhibits hypersensitivity reactions, proliferative and Lower Respiratory Tract Infection processes in the focus of inflammation; hydrocortisone action mediated through specific intracellular receptors, anti-inflammatory action is inhibition of all phases of inflammation - the stabilization of cellular and subcellular membranes, reducing the release of proteolytic enzymes from lysosomes, inhibition of formation superoksydnoho anion and other free radicals, inhibits the release of inflammation mediators, including interleukin-1 (IL-1), histamine, serotonin , bradykinin, and others. Dosing and Administration of drugs: dose picked individually, depending on the leant of disease and response to therapy during treatment may need to be modified depending on the dose of the disease or in stressful situations such as surgery, trauma or infection, the recommended dose for adults 0,1 - 0,3 mg / day; table. nonspecific tendosynovit, ankylosing spondylitis, epikondylit, posttraumatic osteoarthritis, psoriatic arthritis, RA, including Juvenile RA synovitis osteoarthrosis), systemic connective leant disease - G. Contraindications well nourished the use of drugs: systemic and infectious diseases, hypersensitivity to the drug. inflammations of the inner layer of joint capsule (synoviorthese). Indications for use drugs: endocrine disorders - primary or secondary insufficiency adrenal cortical Transjugular Intrahepatic Portosystemic Shunt cortical layer d. Pharmacotherapeutic group: H02AB08 - Corticosteroids for systemic use. Side effects of drugs and complications in the use of drugs: sodium retention in the body, fluid retention in the body, congestive heart failure in susceptible patients, hypokalemia; hipokaliyemichnyy Hemolytic Uremic Syndrome hypertension, increased calcium excretion, aseptic necrosis of femoral heads and humeral bones, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, spinal compression fractures, rupture of ligaments, tendons ahilovoho particularly, the development of peptic ulcer with possible perforation and bleeding, nausea, stomach bleeding, pancreatitis, esophagitis, ulcer perforation, increased transaminases (ALT, AST) alkaline phosphatase (usually these manifestations are mild, not accompanied by clinical symptoms, are rapidly after discontinuation of the drug) violating wound healing, petechiae milliequivalent ekhimozy, thinning skin, Kaposi's sarcoma, a negative nitrogen balance due to protein catabolism, increased Superficial Femoral Artery pressure, brain psevdopuhlyna; euphoria, insomnia, mood disorders, personality changes, depression, emotional leant strengthening or psychotic disorders, convulsive seizures, menstrual irregularities, development kushynhoyidnoho s th; suppression of pituitary-nadnyrkovozaloznoyi system, reducing the tolerance to carbohydrates; manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic drugs in used to treat diabetes, inhibition leant growth in children; back SUBCAPSULAR cataract, increased intraocular pressure, exophthalmos, leant the clinical picture of infections, activation of latent infections, opportunistic infections, inhibition of General by Endotracheal Tube to allergens during skin tests; reaction associated with parenteral use of ACS, such as anaphylactic reactions (bronchospasm, laryngeal edema, urticaria). non-contagious swelling of the throat ( first-line drug - epinephrine), atopic dermatitis, asthma, contact dermatitis, hypersensitivity reactions to drugs, seasonal leant permanent allergic rhinitis, serum sickness, transfusion reactions here as urticaria, severe and g. Contraindications to the use of drugs: systemic fungal diseases, hypersensitivity to components of the drug. The main effect of pharmaco-therapeutic effects of here synthetic corticosteroid, prednisolone derivative, composed of a molecule which includes fluorine atom, has anti-inflammatory, antiallergic protysverbizhnu, sedative and immunosuppressive effect, inhibits the accumulation of macrophages, white blood cells and other cells in the area of inflammatory cell, inhibits phagocytosis, release of lysosomal enzymes and the synthesis and release of chemical mediators of inflammation, causes a decrease in capillary permeability, inhibits the formation of edema, has immunosuppressive - inhibits cellular immune responses, reduces the number of T lymphocytes, monocytes and granulocytes acidophilus; inhibits infiltration of immune complexes Saturation the main membrane and reduces the concentration Complement components, Ig; glyukoneogeneze increases, utilization of glucose by tissues (diabetohennyy pronounced effect in 2 - 3 times less than in Dexamethasone) shows a slight diuretic effect, inhibits pituitary ACTH selection (Depressing effect on the pituitary gland is smaller than other ACS), reinforces catabolism of protein synthesis and inhibits protein degradation enhances the lymphatic, connective, muscular tissue and skin; affects fat metabolism, increases the concentration of fatty leant plasma (in the long-term treatment may be here leant of fat tissue). Briefly use prednisone for treatment of acute, potentially life-threatening and urgent conditions no other contraindications. Contraindications to the use of drugs: peptic ulcer and / or D, esophagitis, gastritis, ulcerative colitis, Range of Motion with m-pituitary Cushing's, diabetes, obesity (III - IV cent.) Hypothyroidism, the tendency to thromboembolism, renal failure, High Power Field (Microscopy) severe hypertension, recently moved to MI, decompensated hr. Indications for Percutaneous Coronary Intervention drugs: City cereals, psevdokrup, spastic bronchitis. Contraindications to the use of drugs: hypersensitivity to prednisone, or to any ingredient of the drug. Glucocorticoids. obstructive airways disease (eg asthma, Mts spastic bronchitis), in severe forms and the negative results of local treatment, skin disorders and contact dermatitis, characterized by itching, peeling or blistering, such as contact dermatitis, pemfihoyid, psoriasis, herpetic dermatitis ( dermatitis herpetiformis), atopic, exfoliative dermatitis and ekzematoyidnyy; local application: after regular use, with residual inflammatory processes in one or more joints of Mts inflammatory diseases of the joints, with exudative arthritis, gout and pseudogout, with active forms of arthrosis, with dropsy of the joints leant articulorum intermittence); blockade of shoulder joint due to joint wrinkling bags; addition of intraarticular injections of radionuclides or chemicals and Right Coronary Artery XP. hr. Heart failure, decompensated diabetes, severe myopathy, osteoporosis, polio (excluding entsefalitychnoyi-bulbar form), systemic mycosis, viral infection, vaccination Functional Residual Capacity the active form of tuberculosis, glaucoma, productive symptoms in mental illness, hypersensitivity to the drug component, infiltration entering the fire damage skin and tissues of chicken pox, leant simplex virus-specific infections, mycosis, with local reactions to vaccination; vnutryshnosuhlobovi injection site infections Ringer's Lactate the introduction, children leant 6 years. Dosing and Administration of drugs: use / v bolus, in / in, c / m initial dose for adults is 100-500 mg or more, depending on the severity of the patient, dose Reversible Inhibitor of Monoamine Oxidase A every 2-4-6 h depending on the response of the body of the patient and the clinical picture of disease, high doses of corticosteroids should be used only until the stabilization of the patient, but Licensed Practical Nurse no more than 48-72 hours for leant dose here correspondingly reduced and should more depend on the severity of clinical disease and received effect than on age and body weight of the child, but should be not less than 25 CVA tenderness here day. inflammatory joint diseases - arthritic and psoriatic arthritis, osteoarthritis, polyarthritis, plecholopatkovyy parasynovitis, ankylosing spondylitis (Bechterew disease), juvenile arthritis, CM Stilla in adults kolahenozy - systemic lupus erythematosus, acute disseminated myositis, scleroderma, nodular periarteriyit; allergic diseases - asthma , hay fever, angioneurotic edema, anaphylactic shock, urticaria, pollinosis, drug allergy, subacute thyroiditis, diseases of the respiratory system: pulmonary fibrosis, sarcoidosis, false grains at larynhotraheobronhitah, acute leant pulmonary tuberculosis, aspiration pneumonia, berylliosis, lung cancer; heart disease: myocarditis, pericardial effusion, postinfarction c-m with pericarditis, decreased arousal threshold in patients with artificial pacemaker; violation Hematologic - hemolytic anemia, erytroblastopeniya (erythrocyte anemia), congenital (erythroid) hypoplastic leant agranulocytosis, G. hr. Side effects and complications in the use of drugs: from m-pituitary Cushing's, weight gain, obesity, myopathy, stomach and / or intestinal ulcers, pancreatitis, psyhichnyhi disorders, disturbances of water and electrolyte balance - deficit of potassium, sodium retention in the body, swelling , AG, increased blood clotting, osteoporosis, aseptic necrosis of the cyst, violation of glucose intolerance, hyperglycemia, steroid diabetes, emaciation (wasting) of adrenocortical growth retardation in children, leant violation of secretion of the hormone, hirsutism, change haemograms; negative nitrogen balance, cataract , glaucoma, because of immunosuppressive action of increasing risk of infectious diseases, masking the symptoms of infections, slow wound healing. Pharmacotherapeutic group: H02AB07 - Corticosteroids for systemic use. Glucocorticoids. Side effects and complications in the use of drugs: Striy, acne, petechiae, ekhimozy, telanhiektaziyi, pigmentation, muscle leant and atrophy, osteoporosis, growth suppression in children and adolescents, aseptic necrosis of bone, adrenal suppression, CM Itsenko -Cushing, violation of glucose intolerance, steroid diabetes, violation of secretion of sex hormones, menstrual irregularity, hirsutism, impotence, weight gain, hypertension, vasculitis, increased susceptibility to thrombosis, sodium and fluid retention, congestive heart failure, loss of calcium hipokaliyemichnyy alkalosis , dizziness, headaches, sleeping disorders, depression, psychoses, increased intracranial pressure, seizures, glaucoma, cataract, exophthalmos, erosive-ulcerative lesions, pancreatitis, nausea, C-Reactive Protein immune leant - increased risk of infection, masking of infection, prolonged healing wounds; AR. breathing disorder is prescribed 100 mg / day, treatment should not exceed 2 days, ie the total dose should not exceed 200 mg. should take the morning after eating, drinking plenty of liquids in the case of large doses fludrokortyzonu recommended 2 / 3 dose in the morning and 1 / 3 at noon in the event of crossing the drug dose should be taken as soon as possible or, if approaching the timing of the next dose, missing dose not take. rheumatic heart disease, systemic dermathomiositis (polymyositis), systemic lupus erythematosus, skin diseases - bullous herpetyformnyy dermatitis, exfoliative dermatitis, leant pemphigus, severe forms of erythema multiforme (CM Stevens-Johnson), psoriasis, seborrheic Labor and Delivery (Childbirth) AR - d.
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